Top Python GitHub Repositories & Open Source Projects (2026)

MCP server that watches video footage and returns license-safe BGM matches, hook windows, and ffmpeg ducking specs for agents.

:house_with_garden: Open source home automation that puts local control and privacy first.

RelateAnything: Real-Time Open-Vocabulary Relation Prediction From Any Inputs

DeepSeek-V4.1-Flash on 3-4x NVIDIA DGX Sparks

A cute, lightweight desktop companion for Linux that idles, reacts, sleeps, and hangs out while you work.

AI agent can create video content better than you. No reason why you do it manually in google flow!

A reactive notebook for Python — run reproducible experiments, query with SQL, execute as a script, deploy as an app, and version with git. Stored as pure Python. All in a modern, AI-native editor.

Awesome projects, built with or for GPUI!

Train transformer language models with reinforcement learning.

Ultra-lightweight, open-source, self-hosted personal AI agent framework in Python with WebUI, tools, memory, MCP, multi-agent workflows, automation, and chat apps

SpeakerMem-R1: Speaker-Centered Dual-Track Memory for Multi-Party Dialogue

A programming framework for agentic AI

Open Reality: phone video to AI-queryable 3D scenes. MCP tools for Claude/Codex/Cursor (npm openreality-mcp), the self-hostable broker, and the VGGT-SLAM library, in one repo. BSD-2-Clause.

A practical hardware and software setup for a compact RL-powered biped robot.

🚀 The fast, Pythonic way to build MCP servers and clients.

Secure, Fast, and Extensible Sandbox runtime for AI agents.

AI conversations that actually remember. Never re-explain your project to your AI again. Join our Discord: https://discord.gg/tyvKNccgqN

The open-source System One decision model. Sub-15ms, non-autoregressive, local drop-in alternative to TypeSafe Jev.

A framework for efficient model inference with omni-modality models

Unified framework for robot learning with multi-physics/renderer support