Top Python GitHub Repositories & Open Source Projects (2026)

RF-DETR is a real-time object detection and segmentation model architecture developed by Roboflow, SOTA on COCO, designed for fine-tuning. [ICLR 2026]

vllm based inference engine for looped transformer

Jev-powered model routing, memory, compaction, skill selection, computer and browser use for Hermes agents (also Claude Code and Codex)

Composable transformations of Python+NumPy programs: differentiate, vectorize, JIT to GPU/TPU, and more

Apache Airflow - A platform to programmatically author, schedule, and monitor workflows

GLM-5.3 Flash EXL3 for 2-4x DGX Sparks

Jev-Mem: System-One Controlled Agentic Memory

Command-line program to download image galleries and collections from several image hosting sites

Automated job search pipeline: fetches roles from company ATS APIs and aggregators, filters and dedupes them, optionally scores fit with Claude, and reviews results in a local web board.

TypeLLM: LLMs with type-safe generation

Curso de SDD (Spec-Driven Development) desde cero

The open, local take on Jev: typed decisions from an LLM, without generating a single token

Automate browser based workflows with AI

Prefect is a workflow orchestration framework for building resilient data pipelines in Python.

A collection of megakernels for TPU

Command-line program to download videos from YouTube.com and other video sites

Stable Diffusion web UI

An open-source, code-first Python toolkit for building, evaluating, and deploying sophisticated AI agents with flexibility and control.

The most comprehensive Claude Code guide: agentic workflows, hooks, skills, MCP servers, quizzes, and production-ready templates. 430K+ lines.

Open Source Algo Trading Platform for Everyone