Top PYTHON GitHub Repositories & Tools (2026)

A collection of useful extensions for Django.

Integrates DISQUS into Django

A complete voice AI building block with telephony integration, featuring real-time speech-to-text, text-to-speech, and LLM-powered conversational agents.

Servidor MCP fiscal brasileiro: CNPJ, NF-e, NFS-e, CT-e, SPED, eSocial, Simples Nacional, Reforma 2026. 44 tools, zero-cadastro, tabelas offline. Python.

Log and visualize multimodal data for robotics and physical AI

Create high-fidelity Codex companions from 2+ photos with local open-weight neural editing and no OpenAI API key.

Production-ready Stripe-like API versioning in FastAPI

Local-first, governed AI agent runtime for Python — embed it in your app, or run it as a CLI or ACP server. Permissions, MCP, memory and audit replay built in.

SortMeRNA: next-generation sequence filtering and alignment tool

pyregex is a Python Regular Expression Online Tester

Python package to perform enrichment analysis from omics data.

quacc is a flexible platform for computational materials science and quantum chemistry that is built for the big data era.

Galactic Dynamics in python

NES emulator for Python with a native C++ core and Gymnasium interface for reinforcement learning and scripted gameplay.

Actuarial reserving in Python, triangle data manipulation, link ratios calculation, and IBNR models.

A modern CSS selector implementation for BeautifulSoup

List of open-source Discord API Libraries

Pure Python framework for writing Juju charms.

Python-based Comprehensive Network Packet Analysis Library

Documentation sites for Python packages: start simple, go deep