Top PYTHON GitHub Repositories & Tools (2026)

Open-Source Software, Tutorials, and Research on Data-Centric AI 🤖

Self-hosted AI gateway for private RAG, natural-language data access, and tool-calling agents.

ID-based RAG FastAPI: Integration with Langchain and PostgreSQL/pgvector

XKNX - A KNX library written in Python

A Python library for connecting securely to your Cloud SQL instances.

Snowflake Snowpark Python API

Junos modules for Ansible

Local MCP work notes with persistent sessions, decisions, evidence and resumable tasks.

📆 Event and occurrence scheduling application for Django

A collection of useful extensions for Django.

Integrates DISQUS into Django

A complete voice AI building block with telephony integration, featuring real-time speech-to-text, text-to-speech, and LLM-powered conversational agents.

Servidor MCP fiscal brasileiro: CNPJ, NF-e, NFS-e, CT-e, SPED, eSocial, Simples Nacional, Reforma 2026. 44 tools, zero-cadastro, tabelas offline. Python.

Log and visualize multimodal data for robotics and physical AI

Create high-fidelity Codex companions from 2+ photos with local open-weight neural editing and no OpenAI API key.

Production-ready Stripe-like API versioning in FastAPI

Local-first, governed AI agent runtime for Python — embed it in your app, or run it as a CLI or ACP server. Permissions, MCP, memory and audit replay built in.

pyregex is a Python Regular Expression Online Tester

Python package to perform enrichment analysis from omics data.

quacc is a flexible platform for computational materials science and quantum chemistry that is built for the big data era.