biocommons/hgvs
Python library to parse, format, validate, normalize, and map sequence variants according to HGVS Nomenclature (https://hgvs-nomenclature.org/).
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+10
STARS · LAST 30 DAYS
1
PER DAY
#1,253
MOST-STARRED Python
| Window | 7 days | 30 days | 90 days |
|---|---|---|---|
| Stars gained | +7 | +10 | +90 |
| Per day | 1 | 1 | 1 |
| Forks gained | +1 | +3 | +10 |
hgvs gained 10 stars in the last 30 days, about 1 a day, and now has 294. It is about 10 years old and has averaged roughly 29 stars a year. It ranks #1,253 among Python repositories and #9,953 across all languages on GitHubRepo.
Trending Record
2
DAYS ON TRENDING
#9708
BEST RANK
Oct 12, 2026
FIRST APPEARANCE
Active
STATUS TODAY
hgvs has maintained a continuous presence across global trending indexes, peaking at #9708. Below is the 30-day activity profile:
💡 Overview
hgvs is an open-source project written in Python: Python library to parse, format, validate, normalize, and map sequence variants according to HGVS Nomenclature (https://hgvs-nomenclature.org/).
Engineered for speed, consistency, and developer ease, it solves common hurdles in bioinformatics, genome-analysis, genomics. It provides clear interfaces, comprehensive configuration options, and seamless integration with existing tools across the modern development stack.
⚡ Key Features
Optimized execution pipeline written in Python for predictable speed.
Zero-friction configuration with comprehensive sensible defaults out of the box.
Cross-platform runtime support across Linux, macOS, and Windows environments.
Strong typing and modular architecture designed for easy extension and maintainability.
Standardized CLI and API interfaces for smooth integration into CI/CD workflows.
Active community maintenance with regular dependency updates and security patches.
📥 Installation
$ pip install hgvs⚙ System Requirements
Platforms
- • macOS
- • Linux
- • Windows
Runtime & Dependencies
Python >= 3.9, pip, virtualenv
Architecture
x86_64, ARM64 (Apple Silicon & Graviton)
🧠 How It Works
hgvs coordinates its core functionality through a modular Python pipeline. It parses configuration parameters, validates inputs, and resolves dependencies asynchronously. By minimizing runtime overhead and keeping allocations localized, it delivers predictable performance in both local development environments and automated production workloads.
🎯 Production Use Cases
Production System Integration
Embed hgvs into Python backend services to handle core application logic.
CI/CD Automated Pipelines
Run automated validation, builds, and integration suites during deployments.
Developer Tooling & Workflows
Accelerate developer onboarding with pre-configured project utilities.
Open Source Extension
Fork and customize internal modules under the repository's open Apache-2.0 license.
🚀 Getting Started
Install hgvs using your package manager: `pip install hgvs`
Initialize your project workspace or configuration file for hgvs.
Import hgvs into your codebase or invoke it directly from your terminal.
Execute your test suite or run `hgvs --help` to verify successful setup.
👍 Strengths
⚠️ Considerations
⇄ Alternatives & Direct Competitors
👥 Who Should Use This
Developers and engineering teams building with Python, seeking reliable, tested, and actively maintained tooling for production workloads.
🏆 Nearby in the Rankings
biocommons/hgvs is currently ranked #9,953 by stars across every repository tracked on GitHubRepo. These are adjacent projects:
| Rank | Repository | Language | Stars | Action |
|---|---|---|---|---|
| #9,945 | rancher/terraform-provider-rancher2 | Go | ★ 295 | Compare ↗ |
| #9,945 | oxc-project/oxc-resolver | Rust | ★ 295 | Compare ↗ |
| #9,945 | joshuakto/fit | TypeScript | ★ 295 | Compare ↗ |
| #9,945 | vizra-ai/vizra-adk | PHP | ★ 295 | Compare ↗ |
| #9,945 | openclaw/clickclack | Go | ★ 295 | Compare ↗ |
| #9,953 | biocommons/hgvs This Project | Python | ★ 294 | |
| #9,953 | jazzband/django-authority | Python | ★ 294 | Compare ↗ |
| #9,953 | resty-gwt/resty-gwt | Java | ★ 294 | Compare ↗ |
| #9,953 | play-co/js.io | JavaScript | ★ 294 | Compare ↗ |
| #9,953 | spring-guides/gs-serving-web-content | Java | ★ 294 | Compare ↗ |
| #9,953 | kubernetes-sigs/cloud-provider-azure | Go | ★ 294 | Compare ↗ |
Frequently Asked Questions
What does hgvs do? +
Python library to parse, format, validate, normalize, and map sequence variants according to HGVS Nomenclature (https://hgvs-nomenclature.org/).
What language is hgvs written in? +
The primary language is Python. Topics include: bioinformatics, genome-analysis, genomics, hgvs, sequencing.
Is hgvs actively maintained? +
Yes, the last recorded push was on Oct 12, 2026 with 35 open issues being tracked.
How many stars does hgvs have? +
hgvs has 294 stars and 101 forks on GitHub.
How does hgvs rank among GitHub repositories? +
With 294 stars, biocommons/hgvs is ranked #9,953 globally across all repositories tracked on GitHubRepo and #1,253 among Python projects.
What license is hgvs distributed under? +
The repository reports a Apache-2.0 license. Always verify the repository LICENSE file for legal terms.
