Top Python GitHub Repositories & Open Source Projects (2026)

Open Source CRM for Startups and enterprises. Django + SvelteKit · Self-hosted · Multi-tenant · Free forever

AI conversations that actually remember. Never re-explain your project to your AI again. Join our Discord: https://discord.gg/tyvKNccgqN

MLX-VLM is a package for inference and fine-tuning of Vision Language Models (VLMs) on your Mac using MLX.

ZenML 🙏: One AI Platform from Pipelines to Agents. https://zenml.io.

ComfyUI node for MiniMax H3 that chains multiple video clips with motion context, disk caching, dynamic image references, audio reference support, and seamless final video/audio decoding.

vLLM plugin for attention-ffn disaggregation support

The AI agent that physically operates a phone — the way you do.

A Python library for running thousands of MuJoCo simulations in parallel on CPU

An agent supervisor and software factory foreman powered by TypeSafe’s Jev model

An AI agent that claws through your network

AI-based stock analysis and trading system

User-friendly, cross-platform SSH connection manager

PostgreSQL-based Task Queue for Python

The music player of today! :city_sunrise:

An AI Gateway, registry, and proxy that sits in front of any MCP, A2A, or REST/gRPC APIs, exposing a unified endpoint with centralized discovery, guardrails and management. Optimizes Agent & Tool calling, and supports plugins.

Claude Code Guide - Setup, Commands, workflows, agents, skills & tips-n-tricks from beginner to power user!

Talk to your Mac. Local whisper.cpp + one Jev (TypeSafe) call per command + macOS automation.

A model for high-frequency mathematical intelligence.

Open Jev implementation with custom finetuning

Flagsmith is an open-source feature flag platform with remote config, experimentation, and self-hosted or cloud deployment options.