Top SCIENCE GitHub Repositories & Tools (2026)

The backend agents build with - Multimodal database, orchestration, and serving in one file

Streamlit — A faster way to build and share data apps.

Rich MySQL Terminal Client with AutoCompletion, Syntax Highlighting, and Dataframes

Statsmodels: statistical modeling and econometrics in Python

PyMuPDF is a high performance Python library for data extraction, analysis, conversion & manipulation of PDF (and other) documents.

Stellarium is a free GPL software which renders realistic skies in real time with OpenGL. It is available for Linux/Unix, Windows, macOS and Haiku. With Stellarium, you really see what you can see with your eyes, binoculars or a small telescope.

cuDF - GPU DataFrame Library

MNE: Magnetoencephalography (MEG) and Electroencephalography (EEG) in Python

Single-cell analysis in Python. Scales to >100M cells.

Lightweight, general, scalable C++ library for finite element methods

Anonymous Github is a proxy server to support anonymous browsing of Github repositories for open-science code and data.

Machine learning with dataframes

Bayesian marketing toolbox in PyMC. Media Mix (MMM), customer lifetime value (CLV), buy-till-you-die (BTYD) models and more.

cBioPortal for Cancer Genomics

Wolfram Language / Mathematica reimplementation in Rust (Wolfram oxidized)

Shared Single-file memory layer for all your agents, sub mili-second RAG over text, photo and video on Apple Silicon.. No Server. No API. One File. Pure Swift

Bindings and ADO.NET Provider for DuckDB

Avogadro libraries provide 3D rendering, visualization, analysis and data processing useful in computational chemistry, molecular modeling, bioinformatics, materials science, and related areas.

Resumable Polymarket indexer: CLOB market metadata plus on-chain trades from Polygon, in one DuckDB file you can query with SQL

Graph deep learning library for materials