Top PYTHON GitHub Repositories & Tools (2026)

Command line interface to the freedesktop.org trashcan.

The Python Package Index

A build system and monorepo management tool for the web ecosystem, written in Rust.

OpenAPI based HTTP Client code generator

WebSocket client for Python

Open-source MCP server for LinkedIn. Give Claude and any MCP-compatible AI agent access to profiles, companies, jobs, and messages.

A library for accelerating Transformer models on NVIDIA GPUs, including using 8-bit and 4-bit floating point (FP8 and FP4) precision on Hopper, Ada and Blackwell GPUs, to provide better performance with lower memory utilization in both training and inference.

Python Toolkit for Causal and Probabilistic Reasoning

Write desktop and web apps in pure Python

Apache Avro is a data serialization system.

An extensible, state-of-the-art framework for columnar compression, and the fastest FOSS columnar file format. Formerly at @spiraldb, now an Incubation Stage project at LFAI&Data, part of the Linux Foundation.

Apache CloudStack is an opensource Infrastructure as a Service (IaaS) cloud computing platform

The AI-Native Search Database. Best for agent storage, it unifies vector, text, structured, and semi-structured data into a single engine. This all-in-one database makes agents smarter, easier to run, and more stable.

OpenNumismat, is intended primarily for registering a collection of coins. But it is also suitable for other types of collectibles - stamps, postcards, badges and more exotic things.

A Python library for reading and writing PDF, powered by QPDF

A static website and blog generator

Single-cell analysis in Python. Scales to >100M cells.

Motor - the async Python driver for MongoDB and Tornado or asyncio

the terminal client for LLMs

Open Source CRM for Startups and enterprises. Django + SvelteKit · Self-hosted · Multi-tenant · Free forever