smith-chem-wisc/MetaMorpheus
Proteomics search software with integrated calibration, PTM discovery, bottom-up, top-down and LFQ capabilities
⚡ Executive Summary & Quick Facts
Authoritative SourceMetaMorpheus is MetaMorpheus is an open-source project written in C#: Proteomics search software with integrated calibration, PTM discovery, bottom-up, top-down and LFQ capabilities..
| Repository | smith-chem-wisc/MetaMorpheus ↗ |
|---|---|
| Primary Category | calibration |
| Language & Stack | C# |
| Software License | MIT |
| Community Traction | ★ 109 stars · ⑂ 51 forks · #17,692 globally |
| Maintenance | ● Active (Last commit: Oct 7, 2026) · 303 open issues |
| Target Audience | Developers and engineering teams building with C#, seeking reliable, tested, and actively maintained tooling for production workloads. |
Star History
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+10
STARS · LAST 30 DAYS
1
PER DAY
#1,040
MOST-STARRED C#
| Window | 7 days | 30 days | 90 days |
|---|---|---|---|
| Stars gained | +0 | +10 | +90 |
| Per day | 1 | 1 | 1 |
| Forks gained | +0 | +3 | +10 |
MetaMorpheus gained 10 stars in the last 30 days, about 1 a day, and now has 109. It is about 10 years old and has averaged roughly 11 stars a year. It ranks #1,040 among C# repositories and #17,692 across all languages on GitHubRepo.
Trending Record
21
DAYS ON TRENDING
#7279
BEST RANK
Sep 29, 2026
FIRST APPEARANCE
Active
STATUS TODAY
MetaMorpheus has maintained a continuous presence across global trending indexes, peaking at #7279. Below is the 30-day activity profile:
💡 Overview
MetaMorpheus is an open-source project written in C#: Proteomics search software with integrated calibration, PTM discovery, bottom-up, top-down and LFQ capabilities.
Engineered for speed, consistency, and developer ease, it solves common hurdles in calibration, database-search, discovery. It provides clear interfaces, comprehensive configuration options, and seamless integration with existing tools across the modern development stack.
⚡ Key Features
Optimized execution pipeline written in C# for predictable speed.
Zero-friction configuration with comprehensive sensible defaults out of the box.
Cross-platform runtime support across Linux, macOS, and Windows environments.
Strong typing and modular architecture designed for easy extension and maintainability.
Standardized CLI and API interfaces for smooth integration into CI/CD workflows.
Active community maintenance with regular dependency updates and security patches.
📥 Installation
$ git clone https://github.com/smith-chem-wisc/MetaMorpheus.git
cd MetaMorpheus⚙ System Requirements
Platforms
- • macOS
- • Linux
- • Windows
Runtime & Dependencies
C# environment and standard tooling
Architecture
x86_64, ARM64 (Apple Silicon & Graviton)
🧠 How It Works
MetaMorpheus coordinates its core functionality through a modular C# pipeline. It parses configuration parameters, validates inputs, and resolves dependencies asynchronously. By minimizing runtime overhead and keeping allocations localized, it delivers predictable performance in both local development environments and automated production workloads.
🎯 Production Use Cases
High-Throughput Storage
Persist and retrieve structured data records with minimal latency and high concurrency.
In-Memory Caching
Accelerate application response times by caching frequently queried database entities.
Analytical Queries
Run aggregate metrics and point lookups across large sets of records.
Distributed Replication
Synchronize state across multiple cluster nodes with strong consistency guarantees.
🚀 Getting Started
Install MetaMorpheus using your package manager: `git clone https://github.com/smith-chem-wisc/MetaMorpheus.git`
Initialize your project workspace or configuration file for MetaMorpheus.
Import MetaMorpheus into your codebase or invoke it directly from your terminal.
Execute your test suite or run `MetaMorpheus --help` to verify successful setup.
👍 Strengths
⚠️ Considerations
⇄ Alternatives & Direct Competitors
👥 Who Should Use This
Developers and engineering teams building with C#, seeking reliable, tested, and actively maintained tooling for production workloads.
🏆 Nearby in the Rankings
smith-chem-wisc/MetaMorpheus is currently ranked #17,692 by stars across every repository tracked on GitHubRepo. These are adjacent projects:
| Rank | Repository | Language | Stars | Action |
|---|---|---|---|---|
| #17,624 | bailo167/awesome-game-mashups | Python | ★ 110 | Compare ↗ |
| #17,624 | leggedrobotics/ame2_minimal | Python | ★ 110 | Compare ↗ |
| #17,624 | phuryn/work-humanizer | Python | ★ 110 | Compare ↗ |
| #17,624 | Danielxu0208/rsi_eval | Python | ★ 110 | Compare ↗ |
| #17,624 | christos-antono/NPCTalk | Python | ★ 110 | Compare ↗ |
| #17,692 | smith-chem-wisc/MetaMorpheus This Project | C# | ★ 109 | |
| #17,692 | telmich/gpm | C | ★ 109 | Compare ↗ |
| #17,692 | sjlombardo/acts_as_network | Ruby | ★ 109 | Compare ↗ |
| #17,692 | robbyrussell/shorturl | Ruby | ★ 109 | Compare ↗ |
| #17,692 | nicksieger/jsonpretty | Go | ★ 109 | Compare ↗ |
| #17,692 | vidageek/mirror | Java | ★ 109 | Compare ↗ |
Frequently Asked Questions
What does MetaMorpheus do? +
Proteomics search software with integrated calibration, PTM discovery, bottom-up, top-down and LFQ capabilities
What language is MetaMorpheus written in? +
The primary language is C#. Topics include: calibration, database-search, discovery, mass-match, proteome.
Is MetaMorpheus actively maintained? +
Yes, the last recorded push was on Oct 7, 2026 with 303 open issues being tracked.
How many stars does MetaMorpheus have? +
MetaMorpheus has 109 stars and 51 forks on GitHub.
How does MetaMorpheus rank among GitHub repositories? +
With 109 stars, smith-chem-wisc/MetaMorpheus is ranked #17,692 globally across all repositories tracked on GitHubRepo and #1,040 among C# projects.
What license is MetaMorpheus distributed under? +
The repository reports a MIT license. Always verify the repository LICENSE file for legal terms.
