Top Python GitHub Repositories & Open Source Projects (2026)

TypeLLM: LLMs with type-safe generation

All Algorithms implemented in Python

Eleven free Claude skills that run a LinkedIn account: posts off 21 hook formulas, comments, replies, profile score, weekly plan, and a humanizer that strips the AI fingerprint and scores the draft before it goes out.

RelateAnything: Real-Time Open-Vocabulary Relation Prediction From Any Inputs

A community-supported supercharged document management system: scan, index and archive all your documents

A list of useful payloads and bypass for Web Application Security and Pentest/CTF

A terminal coding agent that plans work as executable graphs

System 1 decision models (Jev, Laya, Cua-S1) as brain for agents: Browser use, computer use, games and robotics

Local Laya typed decisions on Apple Core ML and Neural Engine. Validated ports, ~5 ms short decisions on M3 Max, reproducible speed and energy benchmarks.

Omnigent is an open-source AI agent framework and meta-harness: orchestrate Claude Code, Codex, Cursor, Pi, and custom agents — swap harnesses without rewriting, enforce policies and sandboxing, and collaborate in real time from any device.

FastAPI framework, high performance, easy to learn, fast to code, ready for production

How Python does AI. Agents, realtime voice, image generation, embeddings. Every model, every interface, typed end to end.

Streaming 3D reconstruction from only video input: Revisiting Local Context for Long-Horizon Streaming 3D Reconstruction

The Memory Layer for AI Agents - Drop-in memory infrastructure for AI agents and apps. Context that persists. Built for production.

Synthadoc: An open-source LLM knowledge compilation engine that turns raw documents into structured, local-first wikis. A transparent, human-readable alternative to traditional RAG, which can be self-managed and self-improved without the use of any tools.

Robust Speech Recognition via Large-Scale Weak Supervision

De-AI writing skill for any Agent Skills-compatible agent (77+ via the Skills CLI), with native plugins for Claude Code, Codex, Grok Build, and Antigravity. Narrative-architecture repair for fiction, venue-matched rules for professional prose. Based on StoryScope (arXiv:2604.03136).

🌟 The Multi-Agent Framework: First AI Software Company, Towards Natural Language Programming

A high-throughput and memory-efficient inference and serving engine for LLMs

SGLang is a high-performance serving framework for large language models and multimodal models.