Top PYTHON GitHub Repositories & Tools (2026)

Graph-Native Infrastructure for Context and Accountable AI Systems

Build voice agents with open-source models

The little ASGI framework that shines. 🌟

Rich MySQL Terminal Client with AutoCompletion, Syntax Highlighting, and Dataframes

Statsmodels: statistical modeling and econometrics in Python

PyMuPDF is a high performance Python library for data extraction, analysis, conversion & manipulation of PDF (and other) documents.

Ollama Python library

cuDF - GPU DataFrame Library

Beautifier for javascript

Apache Beam is a unified programming model for Batch and Streaming data processing.

Build an agent harness and control it end-to-end. Open-source SDK for production AI agents in Python & TypeScript - any model, any cloud.

🧱 easy fast branchable microVM runtime and library for any workload

The source code that powers readthedocs.org

A fast PostgreSQL Database Client Library for Python/asyncio.

A debugging and profiling tool that can trace and visualize python code execution

Open Source Inventory Management System

Fine-tune LLMs from one YAML. Layer streaming trains an 8B model on a 4 GB laptop GPU.

The Enterprise-Grade Multi-Agent Orchestration Framework. Website: https://swarms.ai

Codebase intelligence for AI and humans: code health scores, auto-generated docs, git analytics, dead code detection, and architectural decisions via MCP.

A free, online learning platform to make quality education accessible for all.