Top PYTHON GitHub Repositories & Tools (2026)

A Python wrapper around Synology API

Open Data Cube analyses continental scale Earth Observation data through time

Open-source systems management and configuration platform

Ganeti is a virtual machine cluster management tool built on top of existing virtualization technologies such as Xen or KVM and other open source software.

Live2D Library for Python (C++ impl): Supports model loading, lip-sync, basic face rigging, and precise click test.

Building blocks for Uniswap (V2, V3, V4), Curve V1, Solidly V2, Balancer V2 & Aave V3 arbitrage and liquidation bots on EVM-compatible blockchains

Platform for Machine Learning projects on Software Engineering

Image augmentation for computer vision. AGPL-3.0-only or commercial licensing.

PyLops – A Linear-Operator Library for Python

AI-powered assistant workbench for FreeCAD — generate 3D models from natural language

A powerful browser extension that supercharges DeepSeek Chat with custom tooling, persistent memory, and seamless project scaffolding. Generate and download files, run Python in-browser, create PowerPoint and Excel documents, build multi-file projects as ZIP archives, and manage custom skills and characters.

SDK libraries for Modal

A RAG app to ask questions about rows in a database table. Deployable on Azure Container Apps with PostgreSQL Flexible Server.

Headless chatbot that detects spam and posts links to it in chatrooms for quick deletion.

PyAthena is a Python DB API 2.0 (PEP 249) client for Amazon Athena.

Knowledge-Aware machine LEarning (KALE): accessible machine learning from multiple sources for interdisciplinary research, part of the 🔥PyTorch ecosystem. ⭐ Star to support our work!

FastAPI plugin to enable SSO to most common providers (such as Facebook login, Google login and login via Microsoft Office 365 Account)

Feature Flag Management and A/B Testing platform

Performance analytics, portfolio backtesting, risk analysis, and factsheet reporting in Python

SystemVerilog 2017 Pre-processor, Parser, Elaborator, UHDM Compiler. Provides IEEE Design/TB C/C++ VPI and Python AST & UHDM APIs. Compiles on Linux gcc, Windows msys2-gcc & msvc, OsX