Top Python GitHub Repositories & Open Source Projects (2026)

Chia blockchain python implementation (full node, farmer, harvester, timelord, and wallet)

Node.js native addon build tool

Ollama Python library

Silero VAD: pre-trained enterprise-grade Voice Activity Detector

Lutris desktop client

Open source MCP Servers for AWS

bottle.py is a fast and simple micro-framework for python web-applications.

Light, flexible and extensible ASGI framework | Built to scale

Open GenAI Stack

A configurable set of panels that display various debug information about the current request/response.

Open Vision Agents by Stream. Build voice and vision agents quickly with any model or video provider. Uses Stream's edge network for ultra-low latency.

A fast PostgreSQL Database Client Library for Python/asyncio.

⚡ TabPFN: Foundation Model for Tabular Data ⚡

A sample app for the Retrieval-Augmented Generation pattern running in Azure, using Azure AI Search for retrieval and Azure OpenAI large language models to power ChatGPT-style and Q&A experiences.

MCP Server for Computer Use in Windows

The Enterprise-Grade Multi-Agent Orchestration Framework. Website: https://swarms.ai

BleachBit system cleaner for Windows and Linux

MemoryBear Equip AI with human-like memory capability

A free, online learning platform to make quality education accessible for all.

This is a repository for collecting global custom management extensions for the Django Framework.