Top Python GitHub Repositories & Open Source Projects (2026)

The Semantic Intelligence Layer for Ontologies

An Apple Reminders CLI for power users and AI agents. RemCTL supports all the latest Reminders features such as sections, subtasks, tags, rich links, groceries lists, templates, smart lists, and image attachments. (Not affiliated with Apple.)

Curated list of the best truly open-source AI projects, models, tools, and infrastructure. Daily updated.

AI video processing pipeline for generating vertical shorts using LLMs, Whisper transcription, highlight detection and automated editing

A completely free open-sourced project designed to humanize AI-generated text through a multilingual LLM-powered rewriting pipeline.

DeepInverse: a PyTorch library for solving imaging inverse problems using deep learning

One webpage for every book ever published!

Self-improving AI Employees turning LLM tokens into work and dollars.

Open-source persistent memory for AI agent pipelines (LangGraph, CrewAI, AutoGen) and Claude. REST API + knowledge graph + autonomous consolidation.

The #1 AI Harness for Building Resumes, PDFs, Cover Letters & more, locally with 100+ LLMs support.

Open-source inference server and production cluster for all the models your agent needs.

awesome game security [Welcome to PR]

Open-source Tax Guides for AI agents, reviewed by named CPAs/CAs/EAs. 1,000+ Guides across 190+ jurisdictions. MCP server included. Works with Claude, ChatGPT, Cursor.

PipesHub is an open-source platform for securely connecting enterprise knowledge to AI. Give AI agents trusted context and your team permission-aware search with verified citations across your business systems.

Detail-Oriented Pixelization based on Contrast-Aware Outline Expansion.

Collection of Testflight public app link（iOS/iPad OS/macOS/tvOS/visionOS）

Flagsmith is an open-source feature flag platform with remote config, experimentation, and self-hosted or cloud deployment options.

🔒 Free V2Ray configs auto-updated every 15m | VLESS, VMess, Trojan, Shadowsocks, Hysteria2, TUIC, Reality, WireGuard | subscription link | bypass censorship | Compatible with v2rayNG, Hiddify, NekoRay, NekoBox, v2rayN, Clash Meta, Shadowrocket | xray-core | iran | free vpn | @Raydikalx

The open, local take on Jev: typed decisions from an LLM, without generating a single token

The leading native Python SSHv2 protocol library.